ʻO ka ʻaila ʻaila Macrocephalae Rhizoma kūlohelohe OEM

wehewehe pōkole:

Ma ke ʻano he lāʻau chemotherapeutic maikaʻi, hoʻohana nui ʻia ka 5-fluorouracil (5-FU) no ka mālama ʻana i nā maʻi maʻi maʻi ma ka ʻōpū o ka ʻōpū, ke poʻo, ka ʻāʻī, ka umauma, a me ka ovary. A ʻo 5-FU ka lāʻau lapaʻau mua no ka maʻi maʻi colorectal ma ke keʻena. ʻO ka hana hana o 5-FU ka mea e ālai ai i ka hoʻololi ʻana o ka uracil nucleic acid i thymine nucleic acid i loko o nā pūnaewele tumo, a laila e hoʻopili i ka synthesis a me ka hoʻoponopono ʻana o DNA a me RNA e hoʻokō i kāna hopena cytotoxic (Afzal et al., 2009; Ducreux et. al., 2015; Longley et al., 2003). Eia nō naʻe, hoʻopuka ʻo 5-FU i ka maʻi maʻi chemotherapy-induced (CID), kekahi o nā hopena ʻino maʻamau e hoʻopilikia ai i nā maʻi he nui (Filho et al., 2016). ʻO ka nui o ka maʻi maʻi i nā maʻi i mālama ʻia me 5-FU a hiki i 50% -80%, ka mea i hoʻopilikia nui i ka holomua a me ka pono o ka chemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). No laila, he mea koʻikoʻi ka loaʻa ʻana o ka lāʻau lapaʻau kūpono no 5-FU i hoʻokomo ʻia CID.

I kēia manawa, ua hoʻokomo ʻia nā hana lāʻau ʻole a me nā hana lāʻau i loko o ka lāʻau lapaʻau o CID. ʻO nā hana lāʻau ʻole he ʻai kūpono, a hoʻohui pū me ka paʻakai, ke kō a me nā meaʻai ʻē aʻe. Hoʻohana pinepine ʻia nā lāʻau lapaʻau e like me loperamide a me ka octreotide i ka anti-diarrhea therapy o CID (Benson et al., 2004). Eia kekahi, ua hoʻohana ʻia nā ethnomedicines e mālama iā CID me kā lākou ʻokoʻa kūʻokoʻa ma nā ʻāina like ʻole. ʻO ka lāʻau lapaʻau Kina kahiko (TCM) kekahi ethnomedicine maʻamau i hoʻomaʻamaʻa ʻia ma mua o 2000 mau makahiki ma nā ʻāina ʻĀkia Hikina me Kina, Iapana a me Korea (Qi et al., 2010). Manaʻo ʻo TCM e hoʻomaka ana nā lāʻau chemotherapeutic i ka hoʻohana ʻana i ka Qi, ka hemahema o ka spleen, ka ʻole o ka ʻōpū a me ka endophytic dampness, ka hopena i ka hana ʻino o ka ʻōpū. Ma ke kumumanaʻo TCM, pono e hilinaʻi nui ʻia ka hoʻolālā lapaʻau o CID i ka hoʻonui ʻana i ka Qi a me ka hoʻoikaika ʻana i ka spleen (Wang et al., 1994).

ʻO nā aʻa maloʻo oAtractylodes macrocephalaKoidz. (AM) aPanax ginsengCA Mey. (PG) nā lāʻau lapaʻau maʻamau i TCM me nā hopena like o ka hoʻonui ʻana i ka Qi a me ka hoʻoikaika ʻana i ka spleen (Li et al., 2014). Hoʻohana mau ʻia ʻo AM a me PG ma ke ʻano he mau mea kanu (ʻo ke ʻano maʻalahi o ka hoʻohālikelike ʻana i nā mea kanu Kina) me nā hopena o ka hoʻonui ʻana i ka Qi a me ka hoʻoikaika ʻana i ka spleen e mālama i ka maʻi maʻi. No ka laʻana, ua kākau ʻia ʻo AM a me PG i loko o nā ʻano hana anti-diarrheal maʻamau e like me Shen Ling Bai Zhu San, Si Jun Zi Tang mai.Taiping Huimin Heji Ju Fang(Ka moʻokūʻauhau mele, Kina) a me Bu Zhong Yi Qi Tang maiPi Wei Lun(Yuan dynasty, Kina) (Fig. 1). Ua hōʻike ʻia kekahi mau noiʻi mua e loaʻa i nā ʻano ʻekolu ʻekolu ka hiki ke hoʻēmi i ka CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Eia kekahi, ua hōʻike ʻia kā mākou noiʻi mua ʻana ʻo Shenzhu Capsule nona ka AM a me PG wale nō ka hopena i ka mālama ʻana i ka maʻi maʻi maʻi, colitis (xiexie syndrome), a me nā maʻi ʻeha ʻē aʻe (Feng et al., 2018). Eia naʻe, ʻaʻohe haʻawina i kūkākūkā i ka hopena a me ka hana o AM a me PG i ka mālama ʻana iā CID, inā i hui pū ʻia a i ʻole.

I kēia manawa ua manaʻo ʻia ka microbiota gut he kumu kūpono i ka hoʻomaopopo ʻana i ka hana therapeutic o TCM (Feng et al., 2019). Hōʻike nā haʻawina hou he mea koʻikoʻi ka microbiota gut i ka mālama ʻana i ka homeostasis intestinal. Hāʻawi ka microbiota gut olakino i ka pale mucosal intestinal, metabolism, immune homeostasis a me ka pane ʻana, a me ka hoʻopau ʻana i ka pathogen (Thursby and Juge, 2017; Pickard et al., 2017). Hoʻopilikia ka microbiota gut maʻi i nā hana physiological a me ka pale ʻana o ke kino o ke kanaka ma ke ʻano pololei a ʻaʻole pololei paha, e hoʻoulu ai i nā hopena ʻaoʻao e like me ka maʻi maʻi (Patel et al., 2016; Zhao a me Shen, 2010). Ua hōʻike ʻia nā noiʻi ua hoʻololi ka 5-FU i ke ʻano o ka microbiota gut i nā ʻiole diarrheic (Li et al., 2017). No laila, hiki ke hoʻopili ʻia nā hopena o AM a me PM ma 5-FU i hoʻokomo ʻia i ka maʻi maʻi e ka ʻōpū microbiota. Eia naʻe, inā ʻo AM a me PG wale nō a me ka hui pū ʻana hiki ke pale i ka maʻi maʻi 5-FU ma o ka hoʻololi ʻana i ka microbiota gut ʻaʻole maopopo.

I mea e noiʻi ai i nā hopena anti-diarrhea a me ke ʻano kumu o AM a me PG, ua hoʻohana mākou i ka 5-FU e hoʻohālike i kahi hoʻohālike diarrheal i nā ʻiole. Maʻaneʻi, ua nānā mākou i nā hopena kūpono o ka hoʻokele hoʻokahi a hui pū ʻia (AP) oAtractylodes macrocephalaʻaila nui (AMO) aPanax ginsengka nui o saponins (PGS), nā mea ikaika i unuhi ʻia mai AM a me PG, ma ka maʻi maʻi maʻi, pathology intestinal a me ka microbial structure ma hope o 5-FU chemotherapy.